A Filipino-American professional Basketball Player for the Terrafirma Dyip of the Philippine Basketball Association (PBA). He mostly plays as a point or shooting guard. Enciso played two seasons of basketball at Skyline College, and then he transferred to Notre Dame de Namur University in 2012. Enciso applied for the 2014 NBA draft but was not drafted by any team. He decided to move to the Philippines and applied for the 2014 PBA D-League draft, where he was drafted in the third round by the Cebuana Lhuillier Gems.
Enciso was drafted in the second round by the Rain or Shine Elasto Painters with the 17th overall pick in the 2015 PBA draft. He was then traded to NLEX Road Warriors in exchange for a 2018 second round pick. In his PBA debut for the Road Warriors, he registered 15 points (from five three-pointers), three assists and three rebounds in 28 minutes. On February 18, 2017, he was traded by the Phoenix Fuel Masters to the Alaska Aces in exchange for fellow guard RJ Jazul. On August 26, 2018, Simon Enciso registered a career-high 30 points and 9 three-pointers made in a 121-95 blowout win over the TNT Katropa. On January 6, 2020, Simon Enciso was traded from the Alaska Aces to TNT Tropang Giga for Mike DiGregorio, 2020 first draft pick.